Drug metabolite kinetics: noncompartmental analysis [letter]
نویسندگان
چکیده
منابع مشابه
Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute nonthyroidal illnesses. A noncompartmental analysis.
The low thyroxine (T(4)) state of acute critical nonthyroidal illnesses is characterized by marked decreases in serum total T(4) and triiodothyronine (T(3)) with elevated reverse T(3) (rT(3)) values. To better define the mechanisms responsible for these alterations, serum kinetic disappearance studies of labeled T(4), T(3), or rT(3) were determined in 16 patients with the low T(4) state and com...
متن کاملDrug Metabolite Purifi
Drug metabolism and pharmacokinetics (DMPK) studies require the identifi cation of drug metabolites usually by mass spectrometry (MS), and in later stages of drug development, confi rmation of metabolite structures by NMR. To achieve this, purifi cation of metabolites may be required. In this Application Note, purifi cation of bupropion drug metabolites was achieved using Agilent Automated Puri...
متن کاملLETTER TO THE EDITOR Recommendations for Reporting Metabolite DataW
The last decade has witnessed dramatic advances in our ability to determine the levels of an ever broadening range of metabolites. That said, while transcriptomic approaches provide almost complete coverage (González-Ballester et al., 2010) and proteomics approaches are now capable of detecting upwards of 45% of the cellular protein complement (Baerenfaller et al., 2008), metabolomics is curren...
متن کاملLETTER TO THE EDITOR Recommendations for Reporting Metabolite DataW
The last decade has witnessed dramatic advances in our ability to determine the levels of an ever broadening range of metabolites. That said, while transcriptomic approaches provide almost complete coverage (González-Ballester et al., 2010) and proteomics approaches are now capable of detecting upwards of 45% of the cellular protein complement (Baerenfaller et al., 2008), metabolomics is curren...
متن کاملLETTER TO THE EDITOR Recommendations for Reporting Metabolite DataW
The last decade has witnessed dramatic advances in our ability to determine the levels of an ever broadening range of metabolites. That said, while transcriptomic approaches provide almost complete coverage (González-Ballester et al., 2010) and proteomics approaches are now capable of detecting upwards of 45% of the cellular protein complement (Baerenfaller et al., 2008), metabolomics is curren...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1985
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1985.tb02730.x